abstract：:Thermoresponsive anionic copolymer brushes, poly(N-isopropylacrylamide-co-acrylic acid-co-tert-butylacrylamide) [P(IPAAm-co-AAc-co-tBAAm)], were grafted onto a monolithic silica rod column through surface-initiated atom-transfer radical polymerization (ATRP) to prepare an effective thermoresponsive anionic chromatogra...

journal_title：Biomacromolecules

authors： Nagase K,Kobayashi J,Kikuchi A,Akiyama Y,Kanazawa H,Okano T

更新日期：2014-04-14 00:00:00

abstract：:Effects of poly(ethylene glycol) (PEG) conjugation on peptide interactions with lipid membranes and lipopolysaccharide (LPS) were investigated for KYE28 (KYEITTIHNLFRKLTHRLFRRNFGYTLR), an antimicrobial and anti-inflammatory peptide derived from human heparin cofactor II. In particular, effects of PEG length and locali...

journal_title：Biomacromolecules

authors： Singh S,Papareddy P,Mörgelin M,Schmidtchen A,Malmsten M

更新日期：2014-04-14 00:00:00

abstract：:The maintenance of hepatocyte phenotype and functions remains as a great challenge in the generation of functional liver tissue and in vitro model for drug metabolism studies. The use of hepatocyte coculture systems plays essential roles in the establishment of cell-cell and cell-extracellular matrix communications si...

journal_title：Biomacromolecules

authors： Liu Y,Li H,Yan S,Wei J,Li X

更新日期：2014-03-10 00:00:00

abstract：:Cellulose is the most familiar and most abundant strong biopolymer, but the reasons for its outstanding mechanical performance are not well understood. Each glucose unit in a cellulose chain is joined to the next by a covalent C-O-C linkage flanked by two hydrogen bonds. This geometry suggests some form of cooperativi...

journal_title：Biomacromolecules

authors： Altaner CM,Thomas LH,Fernandes AN,Jarvis MC

更新日期：2014-03-10 00:00:00

abstract：:The oxidation-responsive behaviors of OEGylated poly-L-cysteine homopolypeptides, that is, poly(L-EG(x)MA-C)n, were investigated. These poly-L-cysteine derivatives adopted mixed conformation in water, in which the β-sheet accounted for a significant proportion. Upon oxidation, the thioethers in polypeptide side chains...

journal_title：Biomacromolecules

authors： Fu X,Ma Y,Shen Y,Fu W,Li Z

更新日期：2014-03-10 00:00:00

abstract：:Reduction-sensitive shell-sheddable glyco-nanoparticles were designed and developed based on poly(ε-caprolactone)-graft-SS-lactobionic acid (PCL-g-SS-LBA) copolymer for efficient hepatoma-targeting delivery of doxorubicin (DOX). PCL-g-SS-LBA was prepared by ring-opening copolymerization of ε-caprolactone and pyridyl d...

journal_title：Biomacromolecules

authors： Chen W,Zou Y,Meng F,Cheng R,Deng C,Feijen J,Zhong Z

更新日期：2014-03-10 00:00:00

abstract：:Hydrogels are able to mimic the basic three-dimensional (3D) biological, chemical, and mechanical properties of native tissues. Since hyaluronic acid (HA) is a chief component of human extracellular matrix (ECM), it represents an extremely attractive starting material for the fabrication of scaffolds for tissue engine...

journal_title：Biomacromolecules

authors： Kufelt O,El-Tamer A,Sehring C,Schlie-Wolter S,Chichkov BN

更新日期：2014-02-10 00:00:00

abstract：:We have designed α-helical peptides de novo that can induce aggregation of various kinds of cells by focusing on physicochemical properties such as hydrophobicity, net charges, and amphipathicity. It is shown that peptide hydrophobicity is the key factor to determine capabilities for cell aggregation while peptide net...

journal_title：Biomacromolecules

authors： Yamamoto N,Tamura A

更新日期：2014-02-10 00:00:00

abstract：:Solutions of glucose, cellobiose and microcrystalline cellulose in the ionic liquid 1-ethyl-3-methyl-imidazolium ([C2mim][OAc]) have been examined using pulsed-field gradient (1)H NMR. Diffusion coefficients of the cation and anion across the temperature range 20-70 °C have been determined for a range of concentration...

journal_title：Biomacromolecules

authors： Ries ME,Radhi A,Keating AS,Parker O,Budtova T

更新日期：2014-02-10 00:00:00

abstract：:Liver glycogen, a highly branched polymer of glucose, is important for maintaining blood-glucose homeostasis. It was recently shown that db/db mice, a model for Type 2 diabetes, are unable to form the large composite glycogen α particles present in normal, healthy mice. In this study, the structure of healthy mouse-li...

journal_title：Biomacromolecules

authors： Sullivan MA,Aroney ST,Li S,Warren FJ,Joo JS,Mak KS,Stapleton DI,Bell-Anderson KS,Gilbert RG

更新日期：2014-02-10 00:00:00

abstract：:Nanoparticles (NPs) with high drug loading and pH-responsivity were prepared by nanoprecipitation of a hydrophobic polymer-drug conjugate (PDC). The PDC, polylactide-graft-doxorubicin (PLA-g-DOX), was synthesized by azide-alkyne click reaction to transform acetylene-functionalized PLA into PLA-graft-aldehyde (PLA-g-AL...

journal_title：Biomacromolecules

authors： Yu Y,Chen CK,Law WC,Weinheimer E,Sengupta S,Prasad PN,Cheng C

更新日期：2014-02-10 00:00:00

abstract：:In tissue engineering, incorporation of bone morphogenetic protein-2 (BMP-2) into biomaterial scaffolds is an attractive strategy to stimulate bone repair. However, suboptimal release of BMP-2 remains a great concern, which may cause unfavorable bone formation as well as severe inflammation. In this study, genipin-cro...

journal_title：Biomacromolecules

authors： Zhang Q,Tan K,Zhang Y,Ye Z,Tan WS,Lang M

更新日期：2014-01-13 00:00:00

abstract：:The present study reports the folic acid (FA) functionalized insulin loaded stable liposomes with improved bioavailability following oral administration. Liposomes were stabilized by alternating coating of negatively charged poly(acrylic acid) (PAA) and positively charged poly(allyl amine) hydrochloride (PAH) over lip...

journal_title：Biomacromolecules

authors： Agrawal AK,Harde H,Thanki K,Jain S

更新日期：2014-01-13 00:00:00

abstract：:Dynamic mechanical properties of aqueous solutions of hydroxypropyl methyl cellulose (HPMC) were investigated using oscillatory shear measurements. The structure was investigated with light scattering. A systematic investigation of the frequency dependence of the shear moduli showed that HPMC forms two distinct interp...

journal_title：Biomacromolecules

authors： Shahin A,Nicolai T,Benyahia L,Tassin JF,Chassenieux C

更新日期：2014-01-13 00:00:00

abstract：:Immunological detection has been developed into a sensitive and versatile technique and is based on two requisite elements: targeting antibodies and an indicator, usually in the form of horseradish peroxidase or alkaline phosphatase. The specificity and turnover rate of these enzymes provide an efficient means of sign...

journal_title：Biomacromolecules

authors： Wurtzler EM,Wendell D

更新日期：2014-01-13 00:00:00

abstract：:The development and use of synthetic, cross-linked, macromolecular substrates with tunable elasticity has been instrumental in revealing the mechanisms by which cells sense and respond to their mechanical microenvironment. We here describe a hydrogel based on radical-free, cross-linked poly(ethylene glycol) to study t...

journal_title：Biomacromolecules

authors： Missirlis D,Spatz JP

更新日期：2014-01-13 00:00:00

abstract：:Aberrant expression of histone deacetylases (HDACs) is related to various types of cancer and is associated with increased proliferation of tumor cells. Hence, the detection of HDAC activities is of great significance for medical sciences as well as biological diagnostics. Herein, we report a hyperbranched polyester-b...

journal_title：Biomacromolecules

authors： Yu C,Wu Y,Zeng F,Li X,Shi J,Wu S

更新日期：2013-12-09 00:00:00

abstract：:We investigate the effects of mixing a colloidal suspension of tunicate-derived cellulose nanocrystals (t-CNCs) with aqueous colloidal suspensions of two protein diblock copolymers, EC and CE, which bear two different self-assembling domains (SADs) derived from elastin (E) and the coiled-coil region of cartilage oligo...

journal_title：Biomacromolecules

authors： Haghpanah JS,Tu R,Da Silva S,Yan D,Mueller S,Weder C,Foster EJ,Sacui I,Gilman JW,Montclare JK

更新日期：2013-12-09 00:00:00

abstract：:A new family of cationic dendron-bearing lipids (CDLs) with poly(amidoamine) dendrons of first to third generation (named as A1, A2, and A3, respectively) was synthesized through a synthesis approach that permits facile variation of chemical structures. All CDLs could effectively bind small interfering RNA (siRNA) to ...

journal_title：Biomacromolecules

authors： Zhang Y,Chen J,Xiao C,Li M,Tian H,Chen X

更新日期：2013-12-09 00:00:00

abstract：:The present study focuses on the formation of microcapsules containing catalytically active L-asparaginase (L-ASNase), a protein drug of high value in antileukemic therapy. We make use of the layer-by-layer (LbL) technique to coat protein-loaded calcium carbonate (CaCO3) particles with two or three poly dextran/poly-L...

journal_title：Biomacromolecules

authors： Karamitros CS,Yashchenok AM,Möhwald H,Skirtach AG,Konrad M

更新日期：2013-12-09 00:00:00

abstract：:Novel biodegradable materials with tunable hydrolytic degradation rate are prepared by grafting of phosphonoethylated polyglycidols with polyesters. First, the hydrolytically degradable polyester grafts are attached to polyglycidols partially grafted with phosphonoethylated diethyl esters through chemical-catalyzed gr...

journal_title：Biomacromolecules

authors： Köhler J,Marquardt F,Teske M,Keul H,Sternberg K,Möller M

更新日期：2013-11-11 00:00:00

abstract：:The leading cause of death in the United States is cardiovascular disease. The majority of these cases result from heart failure post-myocardial infarction (MI). We present data providing evidence for use of acetalated dextran (AcDex) microparticles as a delivery vehicle for therapeutics to the heart post-MI. We harne...

journal_title：Biomacromolecules

authors： Suarez S,Grover GN,Braden RL,Christman KL,Almutairi A

更新日期：2013-11-11 00:00:00

abstract：:Electrospinning of cellulose nanocrystals (CNC)/poly(lactic acid) (PLA) emulsions has been demonstrated to be an effective dispersion and alignment method to control assembly of CNC into continuous composite ultrafine fibers. CNC-PLA nanocomposite random-fiber mats and aligned-fiber yarns were prepared by emulsion ele...

journal_title：Biomacromolecules

authors： Li Y,Ko FK,Hamad WY

更新日期：2013-11-11 00:00:00

abstract：:In this work, we have applied an electrospinning method to control wettability and further hydrophobic modification of a hydrophobic polymer mat of poly(vinylidene fluoride-co-hexafluoropropylene). A correlation between the processing parameters, rheological properties of polymer solutions, and electrospinning ability...

journal_title：Biomacromolecules

authors： Ahmed F,Choudhury NR,Dutta NK,Zannettino A,Knott R

更新日期：2013-11-11 00:00:00

abstract：:We demonstrate the formation of polyethylene glycol (PEG) based hydrogels via oxime ligation and the photoinitiated thiol-ene 3D patterning of peptides within the hydrogel matrix postgelation. The gelation process and final mechanical strength of the hydrogels can be tuned using pH and the catalyst concentration. The ...

journal_title：Biomacromolecules

authors： Lin F,Yu J,Tang W,Zheng J,Defante A,Guo K,Wesdemiotis C,Becker ML

更新日期：2013-10-14 00:00:00

abstract：:Supramolecular nanogel, a physically cross-linked nanosize hydrogel, spontaneously self-assembles in aqueous solution via secondary interactions and is thus of great interest in nanomedicine as a drug carrier. We developed a versatile method for supramolecular nanogel self-assembled by electrostatic interaction betwee...

journal_title：Biomacromolecules

authors： Kim K,Bae B,Kang YJ,Nam JM,Kang S,Ryu JH

更新日期：2013-10-14 00:00:00

abstract：:Controlled reeling is a powerful tool to investigate the details of silk processing. However, consistent forced reeling of silkworms is hindered by the significant degree of behaviorally induced variation caused by the animal. This paper proposes silkworm paralysis as a novel method to control the animal and thus in v...

journal_title：Biomacromolecules

authors： Mortimer B,Holland C,Vollrath F

更新日期：2013-10-14 00:00:00

abstract：:A three-dimensional structure consisting of poly(ε-caprolactone) (PCL) nanofibers covered by periodically spaced PCL crystal lamellae, a self-induced nanohybrid shish-kebab (SINSK) structure, was created using electrospinning followed by a self-induced crystallization. The resulting structure that resembles the nanoto...

journal_title：Biomacromolecules

authors： Wang X,Salick MR,Wang X,Cordie T,Han W,Peng Y,Li Q,Turng LS

更新日期：2013-10-14 00:00:00

abstract：:Although doxorubicin (Dox) has been widely used in the treatment of different types of cancer, its insufficient cellular uptake and intracellular release is still a limitation. Herein, we report an easy process for the preparation of redox-sensitive nanogels that were shown to be highly efficient in the intracellular ...

journal_title：Biomacromolecules

authors： Maciel D,Figueira P,Xiao S,Hu D,Shi X,Rodrigues J,Tomás H,Li Y

更新日期：2013-09-09 00:00:00

abstract：:The complement system plays an important role in innate and adaptive immunity, which suggests that complement activation could be exploited as a potential strategy for vaccine adjuvants. Here we explored the potential of chitosan-based microparticles (CS-NH2 MPs) as a vaccine adjuvant with an active surface for comple...

journal_title：Biomacromolecules

authors： Liu Y,Yin Y,Wang L,Zhang W,Chen X,Yang X,Xu J,Ma G

更新日期：2013-09-09 00:00:00

abstract：:Covalently modified albumin (BSA) microparticles were developed for potential use as an adjuvant in mucosal vaccines against hepatitis B. To synthesize consistent protein particles, a covalent approach was proposed to modify BSA. Our strategy was to bond maleic anhydride (MA) molecules to BSA structure by nucleophilic...

journal_title：Biomacromolecules

authors： Sitta DL,Guilherme MR,Garcia FP,Cellet TS,Nakamura CV,Muniz EC,Rubira AF

更新日期：2013-09-09 00:00:00

abstract：:Multicomponent poly(ethylene glycol) (PEG) brushes (i.e., ≥ 2 adjacent PEG brushes) can be used to engineer culture substrates with microscale, nonfouling regions decorated with covalently immobilized ligands that mediate biospecific interactions. However, synthesizing such brushes with orthogonal immobilization chemi...

journal_title：Biomacromolecules

authors： Sha J,Lippmann ES,McNulty J,Ma Y,Ashton RS

更新日期：2013-09-09 00:00:00

abstract：:The coefficient of thermal expansion (CTE) of cellulose nanocrystal (CNC) films was characterized using novel experimental techniques complemented by molecular simulations. The characteristic birefringence exhibited by CNC films was utilized to calculate the in-plane CTE of self-organized and shear-oriented self-stand...

journal_title：Biomacromolecules

authors： Diaz JA,Wu X,Martini A,Youngblood JP,Moon RJ

更新日期：2013-08-12 00:00:00

abstract：:Electrochemically controlled, reversible assembly of biopolymers into hydrogel structures is a promising technique for on-demand cell or drug encapsulation and release systems. An electrochemically sol-gel transition has been demonstrated in regenerated Bombyx mori silk fibroin, offering a controllable way to generate...

journal_title：Biomacromolecules

authors： Lin Y,Xia X,Shang K,Elia R,Huang W,Cebe P,Leisk G,Omenetto F,Kaplan DL

更新日期：2013-08-12 00:00:00

abstract：:Hybrid agarose hydrogels embedded with pH-responsive diblock copolymers micelles were developed to achieve functional hydrogels capable of stimulus-triggered drug release. Specifically, a well-defined poly(ethylene oxide) (PEO)-based diblock copolymer, PEO-b-poly(2-(N,N-diisopropylamino)ethyl methacrylate) (PEO(113)-b...

journal_title：Biomacromolecules

authors： Jin N,Morin EA,Henn DM,Cao Y,Woodcock JW,Tang S,He W,Zhao B

更新日期：2013-08-12 00:00:00

abstract：:We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a facile and versatile technology to prepare engineered nanocoatings for various biomedical applications. Low-fouling coatings on particles were obtained by the formation of multicomposition...

journal_title：Biomacromolecules

authors： Guntari SN,Wong EH,Goh TK,Chandrawati R,Blencowe A,Caruso F,Qiao GG

更新日期：2013-08-12 00:00:00

abstract：:A heterofunctional support for enzyme immobilization may be defined as that which possesses several distinct functionalities on its surface able to interact with a protein. We will focus on those supports in which a final covalent attachment between the enzyme and the support is achieved. Heterofunctionality sometimes...

journal_title：Biomacromolecules

authors： Barbosa O,Torres R,Ortiz C,Berenguer-Murcia A,Rodrigues RC,Fernandez-Lafuente R

更新日期：2013-08-12 00:00:00

abstract：:We show that functionalizing polymer-coated colloidal nanoplatelets with guanosine groups allows synergistic increase of mechanical properties in nacre-mimetic lamellar self-assemblies. Anionic montmorillonite (MTM) was first coated using cationic poly(diallyldimethylammonium chloride) (PDADMAC) to prepare core-shell ...

journal_title：Biomacromolecules

authors： Martikainen L,Walther A,Seitsonen J,Berglund L,Ikkala O

更新日期：2013-08-12 00:00:00

abstract：:For efficient reversal of multidrug resistance (MDR) in chemotherapy for breast cancer, multifunctional self-assembled nanoparticles (MSN) based on a new amphiphilic copolymer consisting of bioreducible poly[bis(2-hydroxylethyl)-disulfide-diacrylate-β-tetraethylenepentamine] and polycaprolactone (PBD-PCL) were constru...

journal_title：Biomacromolecules

authors： Yin Q,Shen J,Zhang Z,Yu H,Chen L,Gu W,Li Y

更新日期：2013-07-08 00:00:00

abstract：:Escherichia coli serogroup O5 comprises two different subgroups (O5ab and O5ac), which are indiscernible from the point of view of standard immunological serotyping. The structural similarities between the O-antigen polysaccharides (PSs) of these two strains are remarkable, with the only difference being the glycosidi...

journal_title：Biomacromolecules

authors： Sarkar A,Fontana C,Imberty A,Pérez S,Widmalm G

更新日期：2013-07-08 00:00:00